Andrew Lucke

Title: Dr

First name: Andrew

Surname: Lucke

Web Site:


Originally I joined the Fairlie lab having spent better than four years in the United Kingdom working on macrocyclic and host/guest chemistries. Looking for somewhat warmer climes it was time to return to Australia. At the time Fairlie group was and continues to do science that is both interesting and potentially useful to society. I have been able to continue my interest in macromolecular chemistry while broadening my experiences towards medicinal chemistry and molecular modelling. It would be great if future medicinal studies were carried through into clinical trials to the benefit of patients."

1          Sumanadasa, S. D. M. et al. Anti-malarial activity of the anti-cancer HDAC inhibitor SB939. Antimicrob. Agents Chemother. (2012). (In Press)

2          Singh, Y. et al. Amyloid Formation from an α-Helix Peptide Bundle Is Seeded by 310-Helix Aggregates. Chem. A Euro. J. 17, 151-160, (2011).

3          Cantley, M. D. et al. Inhibitors of Histone Deacetylases in Class I and Class II Suppress Human Osteoclasts In Vitro. J. Cell. Physiol. 226, 3233-3241, (2011).

4          Cantley, M. D. et al. Histone deacetylase inhibitors and periodontal bone loss. J. Periodont. Res. 46, 697-703, (2011).

5          Wheatley, N. C. et al. Antimalarial histone deacetylase inhibitors containing cinnamate or NSAID components. Bioorg. Med. Chem. Lett. 20, 7080-7084, (2010).

6          Gupta, P. K. et al. Inhibitors selective for HDAC6 in enzymes and cells. Bioorg. Med. Chem. Lett. 20, 7067-7070, (2010).

7          Andrews, K. T. et al. Potent antimalarial activity of histone deacetylase inhibitor analogues. Antimicrob. Agents Chemo. 52, 1454-1461, (2008).

8          Andrews, K. et al. Clinicopathological correlates of cerebral malaria 2007: an update on the progress of the P-falciparum histone deacetylases: enzymes involved in gene regulation as new antimalarial drug targets. Int. J. Parasit. 38, S26-S26 (2008).

9          Lucke, A. J., Boyle, G. M., Parsons, P. G. & Fairlie, D. P. New Cysteine Derivatives with Antiproliferative Activity on Melanoma Cells. Med. Chem. 2, 123-132, (2006).

10       Kahnberg, P. et al. Design, Synthesis, Potency, and Cytoselectivity of Anticancer Agents Derived by Parallel Synthesis from α-Aminosuberic Acid. J. Med. Chem. 49, 7611-7622, (2006).

11       Singh, Y., Stoermer, M. J., Lucke, A. J., Guthrie, T. & Fairlie, D. P. Structural mimicry of two cytochrome b(562) interhelical loops using macrocycles constrained by oxazoles and thiazoles. J. Am. Chem. Soc. 127, 6563-6572, (2005).

12       Lucke, A. J. & Young, D. J. Electrophilic Cleavage of Cyclopropylmethystannanes: An Experimental Comparison of σ-σ and σ-π Conjugation. J. Org. Chem. 70, 3579-3583, (2005).

13       Lucke, A. J., Tyndall, J. D. A., Singh, Y. & Fairlie, D. P. Designing supramolecular structures from models of cyclic peptide scaffolds with heterocyclic constraints. J. Mol. Graphics Modell. 21, 341-355, (2003).

14       Singh, Y., Stoermer, M. J., Lucke, A. J., Glenn, M. P. & Fairlie, D. P. Regioselective Synthesis of Antiparallel Loops on a Macrocyclic Scaffold Constrained by Oxazoles and Thiazoles. Org. Lett. 4, 3367-3370, (2002).

15       Lucke, A., Stirling, C. J. M. & Bohmer, V. Mono- and multi-layers. Calixarenes 2001, 612-626 (2001).

16       Lucke, A. J. & Stirling, C. J. M. in Calixarenes in Action 172-202 (Imperial College Press, 2000).

17       Hassan, A. K. et al. Thin films of calix-4-resorcinarene deposited by spin coating and Langmuir-Blodgett techniques: determination of film parameters by surface plasmon resonance. Mater. Sci. Eng., C 8-9, 251-255, (1999).

18       Davis, F., Lucke, A. J., Smith, K. A. & Stirling, C. J. M. Order and Structure in Langmuir-Blodgett Mono- and Multilayers of Resorcarenes. Langmuir 14, 4180-4185, (1998).

19       Lucke, A. J. & Young, D. J. The regiochemistry of cyclopropylcarbinylstannane ring fission. Tetrahedron Lett. 35, 1609-1612, (1994).

20       Lucke, A. J. & Young, D. J. The electrophilic cleavage of cyclopropylcarbinylstannanes. Confirmation of Traylor's prediction. Tetrahedron Lett. 32, 807-810, (1991).


Former Group Members