Researchers

Frederik Diness

Title: Dr

First name: Frederik

Surname: Diness

Web Site:

E-mail: fdiness@farma.ku.dk

Background:
I am from Denmark and have a background as PhD in medicinal chemistry. I started of with research within carbohydrate chemistry in my masters (The Technical University of Denmark 2001). Then I worked as a chemist in the medicinal industry (Polypeptide Laboratory) for a short period of time before starting my PhD at the Carlsberg Laboratory under supervision of Prof. Morten Meldal. In my PhD project I worked on solid-phase organic chemistry targeting G-Protein coupled receptor ligands and assay development. After obtaining my PhD (2006) I moved to the Department of Medicinal Chemistry, University of Copenhagen to take up a postdoc position within metal organic and heterocyclic chemistry with Prof. Mikael Begtrup. I here worked mainly on the chemistry of perfluoronated aromatic compounds including cross couplings, direct nucleophilic substitution, lithiation and photochemistry. For a long time I have been interested in the work of the Fairlie group particularly the work on cyclic peptides containing oxazoles/thiazoles in the backbone. This has led me to interest in using these peptides as supermolecular tools for mimicking protein surfaces and to join the Fairlie group within this field.

Research interests:
My primary research interests are centered on using amino acids as synthones for synthesis of biological active chiral small constrained scaffolds, peptide mimetics and small peptides. However I have a wide and general interest in organic synthesis, medicinal chemistry, solid-phase chemistry and technologies, photochemistry, peptide mimics/isosters, turn mimics, receptor-ligand/enzyme-inhibitor interactions, drug discovery, assay technology and neurology/brain research.

Publications:
Diness, F. and Meldal, M. Amino Acid Derived 1,4-Dialkyl Substituted Imidazolones.
Protein Science (Biopolymers) - Submitted

Diness, F. and Meldal, M. Imidazolones in Diastereoselective Cyclization Reactions and CuII Catalysed Cross Couplings. Chemistry - A European Journal, 2009, 15, 7044-7047

Diness, F.; Beyer, J. and Meldal, M. Solid-Phase Synthesis of Tetrahydro-β-carbolines and Tetrahydroisoquinolines by Stereoselective Intramolecular N-Carbamyliminium Pictet-Spengler Reactions. Chemistry - A European Journal, 2006, 12, 8056-8066

Hagel, G.; Thastrup, O.; Morten, M.; Wissing, D.; Diness, F. and Nielsen, T.E.
Identification of compounds modifying a cellular response. Patent pending, 2005, WO2005116656

Diness, F. and Meldal, M. Dual Approach to Intramolecular Carbamoyl-Iminium Activated Solid-Phase Pictet-Spengler Reactions. Peptides 2004 - Proceedings of the Third International and Twenty-Eighth European Peptide Symposium Ed.: Flegel, M.; Fridkin M.; Gilon C.; Slaninova J. Kenes International, Geneva, Switzerland 2004, 208-209.

Diness, F.; Beyer, J. and Meldal, M. Synthesis of 3-Boc-(1,3)-oxazinane Protected Amino Aldehydes from Amino Acids and their Conversion into Urea Precursors. Novel Building Blocks for Combinatorial Synthesis. QSAR & Combinatorial Science 2004, 2, 130-144

Wrodnigg, T.M.; Diness, F.; Gruber, C.; Häusler H.; Lundt, L.; Rupitz, K.; Steiner, A.J.; Stütz, A.E.; Tarling, C.A.; Withers, S.G. and Wölfler, H. Probing the aglycon binding site of a β-glucosidase: a collection of C-1-modified 2,5-dideoxy-2,5-imino-D-mannitol derivatives and their structure-activity relationships as competitive inhibitors.
Bioorganic & Medicinal Chemistry 2004, 12, 3485-3495

Nielsen, T.E.; Diness, F. and Meldal, M. The Pictet-Spengler Reaction in Solid-Phase Combinatorial Chemistry. Curr. Opin. Drug Discov. Devel. 2003, 6, 801-814

Former Group Members