Researchers

Aline Dantas

Title: Dr

First name: Aline

Surname: Dantas

Web Site:

E-mail: a.dantasdearaujo@imb.uq.edu.au

I received my BSc degree in Chemistry in 1999 at the Federal University of Pernambuco (UFPE) in Brazil, after completing undergraduate research at the laboratory of Dr. Joachim Demnitz (current Director of Medicinal Chemistry at Poseidon Pharmaceuticals, Denmark), in the area of medicinal chemistry. In 2000, I worked at Novartis Pharma AG in Basel, Switzerland, on the development of greener synthetic routes for the preparative production of bioactive chiral molecules.  In 2005, I received my PhD degree in Chemical Biology at the Max Planck Institute of Molecular Physiology in Dortmund, Germany, under supervision of Prof. Herbert Waldmann, where my research interests were focused on peptide and protein chemistry and novel bioconjugation techniques.

Since 2005, I have been a research officer at the Institute for Molecular Bioscience, where my research focus has been on the discovery of novel bioactive peptides and the development of peptide drugs from venoms and other sources. 

Publications

Aline Dantas de Araujo, Caspar Christensen, Jens Buchardt, Stephen B. H. Kent, Paul F. Alewood, “Synthesis of a tripeptide mimetic based on dihydroquinolinone and benzoxazinone scaffolds”, Chemistry - an European Journal, 2011, 17, 13983-13986.

Aline Dantas de Araujo, Brid Callaghan, Simon T. Nevin, Norelle L. Day, David J. Craik, Melissa Moretta, Gene Hopping, Macdonald J. Christie, David J. Adams, Paul F. Alewood, “Total synthesis of analgesic conotoxin MrVIB via selenocysteine-assisted folding”, Angewandte Chemie International Edition, 2011, 50, 6527-6529.

Markus Muttenthaler, Asa Anderson, Aline Dantas de Araujo, Zoltan Dekan, Richard J. Lewis, Paul F. Alewood; “Modulating oxytocin activity and plasma stability by disulfide bond engineering”, Journal of Medicinal Chemistry, 2010, 53, 8585-8596.

Markus Muttenthaler, Yesica G. Ramos, Debbie Feytens, Aline Dantas de Araujo, Paul F. Alewood: “p-Nitrobenzyl protection for cysteine and selenocysteine: a more stable alternative to the acetomidomethyl group”, Biopolymers, 2010, 94, 423-432.

Mehdi Mobli, Aline Dantas de Araújo, Lynette K. Lambert, Gregory K. Pierens, Monique J. Windley, Graham M. Nicholson, Paul F. Alewood, Glenn F. King; “Direct Visualization of Disulfide Bonds through Diselenide Proxies Using 77Se NMR Spectroscopy”, Angewandte Chemie International Edition, 2009, 49, 9312-9314; Angewandte Chemie, 2009, 121, 9476-9478.

Aline Dantas de Araújo, Jose M. Palomo, Janine Cramer, Oliver Seitz, Kirill Alexandrov and Herbert Waldmann; “Diels-Alder Ligation of Peptides and Proteins”, Chemistry – an European Journal, 2006, 12, 6095-6109.

Aline Dantas de Araujo, Jose M. Palomo, Janina Cramer, Maja Kohn, Hendrik Schroder, Ron Wacker, Christof Niemeyer, Kirill Alexandrov, Herbert Waldmann, “Diels-Alder Ligation and Surface Immobilization of Proteins”, Angewandte Chemie International Edition, 2006, 45, 296-301; Angewandte Chemie, 2005, 118, 302-307.

Aline Dantas de Araújo, “Diels-Alder Ligation of Peptides and Proteins”, PhD thesis, Dortmund Universität, 2005.

Aline Dantas de Araújo, "Estudos da Redução de Isoxazolinas como Rota Sintética de b-Hidroxicarbonilas" Diplom dissertation, Universidade Federal de Pernambuco, 2000.

Aline Dantas de Araújo, Edmond Bacher, F. W. Joachim Demnitz and Douglas A. Santos; “A Mild Method for the Preparation of 8-Substituted Xanthines from 5,6-Diaminouracils”, Heterocycles, 1999, 51, 29-36.

Former Group Members